Flow Through Cell Dissolution System USP Apparatus IV
Designed to reveal formulation differences that conventional USP Apparatus 1 and 2 might miss, this system is especially effective for poorly soluble drugs, modified/extended release formulations, and low-dose products. With growing relevance in IVIVC (in vitro–in vivo correlation) studies and non-traditional dosage forms, the USP Apparatus 4 continues to evolve, adapting to the dynamic needs of modern pharmaceutical testing.
Product Description
Main Unit: F7 Smart
- 7″ Capacitive Touch Screen display with user friendly interface (UI)
- 6+1 Test units
- Practically unlimited sample intervals
- Digital temperature sensors for Individual cell temperature monitoring
- Position Sensor for individual cell detection
- Temperature range 20-55°C, Temperature accuracy of = =0.1°C at
37°C (flow 16 ml/min)
- Inbuilt validation program for temperature, flow & syringe pump volume
- Indication of cell/Filter blockage during run
- Vibration free – external temperature controller
- Unlimited method & analysis data storage
- 21 CFR part 11 compliance software
- USB, WiFi, LAN Connectivity for backup & restore as well as printers
Universal Sample Collector (C07)
- New Image Required
- Automatic Sample Collection and Waste Collection
- Auto Tray detection as well as “No Tray” error indication
- Color Indication for Auto/Manual Sampling & Ready Condition with single Multi color LED
- Easy to convert system from Open Loop to Closed Loop and vice-Versa.
Open Loop Configuration-
- 13×7 Sample Collection Tray
- 1mlto 80ml fraction collection using Split Function
- Splitter Valve Block
Closed Loop Configuration-
- 24×7 Sample Collection Tray (Testtube and HPLC Vials Tray)
- Media Handling Range: 15ml to 5000ml
- Media Transfer Unit with Digital Temperature control &stirrer.
Media Selector(MS57)
- 5 port Media selector
- Automated media change for 4 Different Media
- Dedicated port for Water as Cleaning Media
- Waste Collection Port for Clean Cycle
Piston Pump(PP07)
- Flow Range: 1.5 ml/min – 36 ml/min
- Flow Accuracy: Betterthan + 5% (USP Limit)
- PPM: 120 = (As per USP Requirement)
- Individual Flow set for Individual pump
- 7 Valveless chemically inert ceramic pump heads
- Inbuilt Calibration/Validation Program-By volume or by weight method
The system’s design supports nearly every dosage form—from standard tablets and capsules to complex drug-eluting implants and semi-solids. Labindia works closely with pharmaceutical innovators to develop custom flow-through cells, optimizing dissolution methods for emerging drug delivery platforms. Whether you’re evaluating microspheres, parenterals, or coated ocular devices, the flow-through system adapts to diverse solubility profiles and dosage geometries while ensuring compliance with global pharmacopeial standards.
Enhanced Versatility
